From NPR News in Washington, I'm Nora Raum. A bomb exploded at a busy market in southwest Pakistan today. Police say at least 63 people were killed, at least 180 others were wounded. The attack occurred in a Shiah Muslim neighborhood in the city of Quetta, which has been targeted several times in recent months by hardline Sunnite militants. On March 1st to cross the board spending cuts that will reduce federal spending by 85 billion dollars beginning to take effect. NPR's Brian Naylor reports the Obama administration is starting to sound the warning bell. What's known as a sequestration in Washington speak will cut domestic spending by 5% and the defence budget by about 8%, its effects will be widespread, any government employees will face temporary layoffs or full loads. Air travelers may be confronted with longer lines at security because of fewer TA screeners and then delays in getting off ground due to fewer air traffic controllers. Homeland security says there will be fewer boots on the ground patrolling the border with Mexico.