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Alzheimer's disease has no cure. There are, however, five drugs—known and approved-that can slow down the development of its symptoms. The earlier such drugs are administered, the better. Unfortunately, the disease is usually first noticed when people complain to their doctors of memory problems. That is normally too late for the drags to do much good. A simple and reliable test for Alzheimer's that can be administered to everybody over the age of about 65, before memory-loss sets in,would therefore be useful.
Theo Luider, of the Erasmus University Medical Centre in Rotterdam, and his colleagues think they have found one-but it works only in women. They made their discovery, just reported in the Journal of Proteome Research9 by tapping into a long-term,continuing study that started in 1995 with 1,077 non-demented and otherwise healthy people aged between 60 and 90. At the banning of the project, and subsequently during the periods 1997-99 and 2002 - 04, participants were brought in for a battery of neurological (神经学的)and cognitive investigations, physical examinations,brain imaging and blood tests.
During the first ten years of the study. 43 of the volunteers developed Alzheimer's diseases. When Dr.Luider compared blood samples from these people with samples from 43 of their fellow volunteers, matched for sex and age, who had remained Alzheimer's-free, he found something startling. Levels of a substance called pregnancy zone protein had been unusually high, even before their symptoms appeared, in some of those who went on to develop Alzheimer's disease.
Those "some",it turned out, were all women. On average, levels of pregnancy zone protein in those women who went on to develop Alzheimer's were almost 60% higher than those of women who did not. In men, levels of the protein were the same for both.
The reason for this curious result seems to be that the brain plaques (斑块)associated with Alzheimer,s disease are themselves turning out pregnancy zone protein. Certainly,when Dr. Luider applied a chemical stain specific to that protein to the plaques of dead Alzheimer's patients he found the protein present in them.
Confusingly,though, it was there in the plaques of both sexes. Presumably, female cells (and therefore the plaques of female brains) make more of it than male ceils do. But that remains to be proved. Whatever the reason, however, this result means that women, at least, may soon be able to tell whether and when they are at risk of Alzheimer's and thus do something about it before they start losing their minds.
1
What can we learn from the first paragraph?
A.No medication can slow down the development of Alzheimer's symptoms.
B.People who always complain are most likely to have Alzheimer's disease.
C.Doctors had better tackle Alzheimer's disease when people are 65 years old.
D.To detect Alzheimer's disease before memory loss appears is crucial.
本题答案:
  • A
  • B
  • C
  • D
  • 参考答案:D
  • 系统解析:
    细节题。第一段最后一句提到,如果有一种简单、可靠的方法,能在患者记忆力减退前检测出该病,且适用于任何65岁年龄以上的人,这种方法会大有裨益,所以D.“在患者记忆力减退前诊断出阿尔茨海默病是很重要的”陈述正确,故为正确答案,同时可知C.是对这句话字面意思的曲解,故排除;根据本段第二句“然而,有五种药物可以减缓阿尔茨海默病症状的恶化”可知,有药物可以缓解阿尔茨海默病症状,故排除A.;B.是对本段第四句“不幸的是,当人们开始向医生抱怒记 忆力问题时,这种病才开始被注意到”的字面意思的曲解,故排除。
2
The word "non-demented" in Paragraph 2 probably means_____.
A.physically disabled
B.unconscious
C.mentally clear
D.low-spirited
本题答案:
  • A
  • B
  • C
  • D
  • 参考答案:C
  • 系统解析:
    语义题。根据第二段第二句“1,077 non-demented and otherwise healthy people aged between 60 and 90”可知,调查研究的对象是1077名60到90岁之间的“non-demented”和“healthy” 的人,其中的“and otherwise”表明这两个词在意思上是并列、递进的关系;再根据第三段前两句可知,在研究的前十年里,志愿者中有43人患上了阿尔茨海默病,后面又将这些患阿尔茨海默病的病人与未患病者进行比较。综上所述,可以推出C.“神志清醒的”为正确答案。A.、B.和D.均不符合文意,故排除。
3
What does Dr. Luider's study tell us about the pregnancy zone protein?
A.It never increase before the symptoms of Alzheimer's appear.
B.In men, level of it remain stable for their lifetime.
C.Women developing Alzheimer's usually have lower levels of it.
D.The brain plaques connected with Alzheimer's produce it.
本题答案:
  • A
  • B
  • C
  • D
  • 参考答案:D
  • 系统解析:
    细节题。第五段第一句提到,出现这一奇怪结果的原因似乎是,与阿尔茨海默病有关联的脑部斑块自身会产生妊振区带蛋白,故D. “与阿尔茨海默病有关的大脑斑块产生妊振区带蛋白质”;为正确答案。根据第三段最后一句可知,在一些患者的阿尔茨海默病症状出现之前,妊振区带蛋白质也异常地高,故排除A.;根据第四段可知,出现上述症状的多为女性,而男性则不同,他们患有阿尔茨海默病之前和之后,妊振区带蛋白质的水平是一致的,所以C.陈述错误,故排除;同时可知 B.为本句意思的曲解,故排除。
4
How does the author feel about Dr. Luider's study?
A.Confuse
B.Optimistic
C.Indifferent
D.Meaningless
本题答案:
  • A
  • B
  • C
  • D
  • 参考答案:B
  • 系统解析:
    态度题。根据本文最后一句可知,但不管是什么原因,这一发现至少意味着女性可以尽早得知其是否会患有阿尔茨海默病,以及什么时候可能患上阿尔茨海默病——因此,医生可以在她们记忆力减退前采取一些措施。可见,作者对这项研究持乐观的态度,故正确答案为B.“乐观的”。
5
The passage is mainly about_____.
A.the development stages of Alzheimer's disease
B.the pregnancy zone protein
C.a new discovery concerning Alzheimer's disease
D.patients of Alzheimer's disease
本题答案:
  • A
  • B
  • C
  • D
  • 参考答案:C
  • 系统解析:
    主旨题。本文开篇第一段指出阿尔茨海默病是难以治愈和难以发现的,并指出阿尔茨海默病预防治疗的一个重要环节,即在患者记忆力减退前诊断出该症状;接下来,第二到四段详述了关于阿尔茨海默病的一项新发现——女性阿尔茨海默病患者体内的妊振区带蛋白质含量比未患此病的女性高很多,甚至在还未患上阿尔茨海默病之前,这些女性患者体内的妊娠区;带蛋白质的含量已经相当的高;第五段分析了出现这一现象的原因;最后一段分析了该实验未解决的疑问以及肯定了这一新发现的意义,综上所述,本文都是围绕“阿尔茨海默病领域的一项新发现”展开的,故C.为正确答案。
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